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H908

Methaemoglobinaemia is a disorder caused by an excess of methaemoglobin in the blood, which can cause lethargy, shallow breathing and increased heart rate.

Working days 10

Caractéristiques

Breeds

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Gene

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Organ

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specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue, Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

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Chromosome

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Year Published

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Informations générales

Methaemoglobinaemia is a disorder caused by an excess of methaemoglobin in the blood, which can cause lethargy, shallow breathing and increased heart rate. This variant, found in the Pomeranian, is caused by a recessive mutation to the CYB5R3 gene. Another variant has been observed in a mixed-breed dog.

Caractéristiques cliniques

Observed symptoms include coughing, shortness of breath, exercise intolerance, increased heart rate and cyanosis (blue coloration) of the membranes of the mouth and genitals. Affected dogs may also respond aggressively when touched on the head or neck. Increased methaemoglobin levels can be confirmed via blood analysis.

Informations Complémentaires

Références

Pubmed ID: 29356095

Omia ID: 2131

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