Haemophilia B is a coagulation disorder caused by defects in the large and complex coagulation factor IX gene. The bleeding predisposition associated with haemophilia A results from a deficiency or dysfunction of IX, with the severity depending on the amount of residual enzyme activity.
Test specific information
This disease leads to a reduction in the number of liveborn offspring. Depending on the disease, affected individuals may be stillborn or aborted.
Turn Around Time
The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.
Location of disease or trait
This disease affects the composition of the blood, consequently influencing the coagulation of blood.
This DNA test is available for the following breeds: Housecat Longhair, Housecat Shorthair. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Swab, Blood EDTA, Blood Heparin, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
The following results are possible for a female: the mode of inheritance is based on recessive or dominant patterns.
The following results are possible for a male:
- A male animal has the sex chromosome Y and a healthy allel. When used in breeding, this animal will not become affected by the disease, nor will the disease be inherited to the next generation.
- A male animal has the sex chromosome Y and a disease allel. When used in breeding, this animal will become affected by the disease. Also, male offspring will receive the Y-chromosome, whereas female offspring will receive the disease allele.
The disease is inherited in an X-chromosomal manner. This means, that female individuals can be free (homozygous normal), affected (homozygous affected) or carrier (heterozygous).
Male individuals carry only one copy of the X-chromosome, which results in the effect that male carriers will also be affected.
Female carriers may spread the disease in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a disease.
Severity of Disease