Zoolyx NV

H417 Leukoencephalomyelopathy


Spongiform leukoencephalomyelopathy shows widespread vacuolation of white matter of the brain and spinal cord. Affected dogs developed tremors at 2 –9 weeks of age followed by progressive neurological worsening nerve dysfunction.

Test specific information



Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease leads to a loss of brain function.

Breed dependence

This DNA test is available for the following breeds: Australian Cattle Dog, Sheepdogs. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Swab, Semen. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.


The following results are possible:

An animal can be free. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be affected.
All offspring of affected females will also receive the disease allele. Affected females will also become ill.
Affected males will become ill. When used in breeding, the disease will not be inherited to the next generation.


The mutation is present in the mitochondrial DNA. Mitochondrial DNA is only inherited through maternal lines. This means, that all offspring of affected female individuals will also be affected.

Both male and female individuals can become affected by this disease.

Affected male individuals cannot spread the disease in the population.

Severity of Disease


Code H417


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