H421 Hiplaxity 2

Background

Laxity of the hip joint is a frequent disorder in dogs. The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Hip Laxity has two main characteristics:
• Laxity: This can be defined by ‘an abnormal freedom of movement of the bone in the hip joint’. As a result, the hip is less stable compared to healthy dogs.
• Ossification and bone formation. In younger dogs, the normal process of bone formation can be slowed down.

Both Laxity and Ossifcation disorders lead to the development of artrosis when dogs mature. Dogs which are affected most can already express symptoms after a few months. Other affected dogs develop artrosis at later ages.

This marker is part of a panel of genetic factors influencing hip laxity.

Test specific information

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Age

The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease is located in the hip.

Breed dependence

For this test samples from all breeds are accepted.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Swab, Tissue, Semen. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment. This marker is part of a panel of genetic factors influencing hip laxity (i.e. an abnormal freedom of movement of the bone in the hip joint). This abnormal movement can be well compensated by the muscles of this particular region, which sometimes leaves the defect unobserved although the animals bear the potential risk to develop a hip-laxity. On the other hand, hip-laxity does not mean hip dysplasia (HD). HD could be the consequence of an ignored physically existing hip-laxity on the long term.
For each genetic factor of a multifactorial disease, the desirable genetic variant is indicated as favorable (N) and unfavorable (HL).
N/N: The animal has two copies of the favorable allele and no increased risk for hip laxity. When used in breeding, none of the offspring will receive the unfavourable allele.
N/HL: The animal has one copy of the favorable allele and one copy of the unfavorable allele. The animal has an increased risk for hip laxity. When used in breeding, 50% of the offspring will receive the unfavorable allele.
HL/HL: The animal has two copies of the unfavorable allele. The animal has an increased risk for hip laxity. When used in breeding, all offspring will receive the unfavorable allele.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.
This marker is part of a panel of genetic factors influencing hip laxity.

Severity of Disease

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Code H421

Hiplaxity 2

€ 47,80 (Incl. 21% VAT)
€ 39,50 (Excl. VAT)
Quantity