Laryngeal paralysis (LP) in dogs is a condition in which the function of nerves and muscles that control the movements of one or both arytenoid cartilages of the larynx is impaired, and instead of opening during aspiration and closing during swallowing, the arytenoids remain stationary in a somewhat neutral position. A wide range of non-hereditary and hereditary forms of LP exist in dogs. One of the most common forms of laryngeal paralysis develops in older, medium to large breed dogs. This idiopathic largyngeal paralysis turned out to be the most visible symptom of a slowly progressing polyneuropathy of old age and is now called geriatric onset laryngeal paralysis polyneuropathy (GOLPP). Diagnosis of LP is based on clinical signs which can overlap in different laryngeal diseases. A genetic study conducted on Miniature Bull Terriers lead to the identification of a major genetic risk factor for an early onset form of LP in this breed. The nonfunctional recessive risk allele results from an insertion into the RAPGEF6 gene. Homozygosity for the insertion lead to an approximately 10- to 17-fold increased risk for LP. However, the genotype-phenotype association is not perfect suggesting a complex mode of inheritance, with other genetic and environmental factors contributing to the disease. The risk allele was exclusively found in Miniature Bull Terriers and Bull Terriers.
Test specific information
Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.
The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.
The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
This DNA test is available for the following breeds: Bull Terrier, Miniature Bull Terrier. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Swab, Tissue, Blood EDTA, Blood Heparin, Semen. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
The disease is of multifactorial origin, which means that
the symptoms are combination of genetic factors as well
as the environment. This marker is part of a panel of
genetic factors influencing this disease.
The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.
Severity of Disease